4 edition of Introduction of structural perturbations into drug polymers found in the catalog.
Introduction of structural perturbations into drug polymers
Thesis (M.A.Sc.) -- University of Toronto, 2003.
|Series||Canadian theses = -- Th`eses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative.|
The first reference book to cover DLCs, Chemistry of Discotic Liquid Crystals: From Monomers to Polymers highlights the chemistry and thermal behavior of DLCs. Divided into six chapters, each with a general description, background, and context for the concepts involved, the book begins with a basic introduction to liquid crystals, describing. The 2nd Proteome- Targeted Drug Discovery Summit will unite large pharma and innovative biotech, as well as key opinion leaders in academia, to develop robust structural and biochemical tools to open up the full therapeutic opportunity held within the entire proteome.
Book Chapters. 1. Vaidehi N and Goddard III W.A. , chapter 6, pp title "Atomic-Level Simulation and Modeling of Biomacromolecules” in the book titled "Computational Modeling of Genetic and Biochemical Networks” Editors Hamid Bolouri and James M. Bower, MIT Press. 2. It has already been suggested by researchers that there should be multiple intermediate states in the activation process for G-protein-coupled receptors (GPCRs). However, the intermediate states are very short-lived and hardly captured by the experiments, leading to very limited understanding of their structural features and drug efficacies. In this work, a novel joint strategy of targeted Cited by: 1.
Protein crystallization was discovered by chance about years ago and was developed in the late 19th century as a powerful purification tool and as a demonstration of chemical purity. The crystallization of proteins, nucleic acids and large biological complexes, such as viruses, depends on the creation of a solution that is supersaturated in the macromolecule Cited by: As such, research into the role of starch-based polymers for 3D bioprinting has been commenced, in particular for bone tissue engineering (Gomes et al., ; Salgado et al., ; Martins et al., ). However, further research needs to be undertaken to ascertain its validity as a viable bioink for multi-tissue bioprinting by: 3.
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Introduction. Biomaterials can be derived either from nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers, ceramics or composite are often used and/or adapted for a medical application, and thus comprises whole or part of a living structure or biomedical device which performs, augments.
Introduction of various alkyl groups on the ferrocene backbone, namely, tert-butyl, isopropyl, and trimethylsilyl, has a significant influence on the stereoselectivity of the ensuing lithiation. Masoud Soroush, Michael C. Grady, in Computational Quantum Chemistry, Solvent Effects. Solvent molecules have been reported to affect the stability of transition state structures in solution free-radical polymerization .The solvent stabilization effect can cause Introduction of structural perturbations into drug polymers book differences between rate coefficients calculated using computational quantum chemistry in the.
The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Intercalates resulted in strong structural perturbations in DNA because drug is established rigidly and perpendicularly to the axis of the double helix, which causes the pairs to be separated. The diversity of chitosan structural types depend on the experimental conditions (kind and concentration of acid, temperature and salt preparation) used for the conversion of chitin into chitosan.
The helical structure propensities can be determined according to the repeating unit and helical symmetry as observed in chitosan crystal structures Cited by: The structural and dynamical properties of the peroxisome proliferator-activated receptor γ (PPARγ) nuclear receptor have been broadly studied in its agonist state but little is known about the key features required for the receptor antagonistic activity.
Here we report a series of molecular dynamics (MD) simulations in combination with free energy estimation of the Cited by: 8. Synthetic polymers such as polyethylene, nylon, and polyurethane have revolutionized the daily life. The word polymer originated from the Greek terms -poly and -mer, which mean “many parts.” Polymeric substances are made up of many chemical units called monomers, which are combined together into large molecular chains containing thousands Cited by: 6.
Pair your accounts. Export articles to Mendeley. Get article recommendations from ACS based on references in your Mendeley library. Hydrogen Bonding. The establishment of hydrogen bonds between sugars and their receptors constitutes perhaps the most evident lectin-carbohydrate bonding potential due to the existence of numerous -OH groups in all saccharides (Fig.
1 1).Furthermore, hydrogen bonding is made possible not only thanks to the hydroxyl groups, but also to the presence of amine and Cited by: Structures of integral membrane receptors provide valuable models for drug–receptor interactions across many important classes of drug targets and have become much more widely available in recent years.
However, it remains to be determined to what extent these images are relevant to human receptors in their biological context and how subtle issues such as subtype selectivity Cited by: In-cell nuclear magnetic resonance (NMR) is a method to provide the structural information of a target at an atomic level under physiological conditions and a full view of the conformational changes of a protein caused by ligand binding, post-translational modifications or protein–protein interactions in living cells.
Previous in-cell NMR studies have focused on proteins that were Cited by: 1. where x = k 2 R g 2 and R g is the radius of gyration. Moreover, the bond correlation effect becomes important for the semiflexible  and rigid chain .From the structure factor, the size and architectures (linear, ring or dendrimer) of the polymers can be studied by the scattering experiment .Furthermore, predicting the property of material from its structure is one of the Author: Xiangyu Bu, Xinghua Zhang.
Many techniques for the synthesis of conductive polymers have been developed. Most conductive polymers are prepared by oxidative coupling of monocyclic precursors. One challenge is usually the low solubility of the polymer. An important property of the electrically conductive reinforced polymer is the positive temperature coefficient (PTC) by: 2.
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine disrupting chemicals, or endocrine disrupting compounds are chemicals that can interfere with endocrine (or hormonal) disruptions can cause cancerous tumors, birth defects, and other developmental disorders.
Found in many household and industrial products. Membrane proteins perform a host of vital cellular functions. Deciphering the molecular mechanisms whereby they fulfill these functions requires detailed biophysical and structural investigations.
Detergents have proven pivotal to extract the protein from its native surroundings. Yet, they provide a milieu that departs significantly from that of the biological membrane, to the Cited by: This book provides a general introduction to nanogels, and designs of various stimuli-sensitive nanogels that are able to control drug release in response to specific stimuli.
Nanogels are three-dimensional nanosized networks that formed by physically or chemically crosslinking polymers. The overwhelming number of known polymers can be basically sub-divided into those for structural applications and those, which come over with specific functions. The former ones as well as the later ones, called Functional Polymers, play important roles since the early days of polymer science and technology.
The latter ones, however, usually. Complex fluids 12 are bulk multicomponent systems that self-assemble into a variety of structural forms. Such systems include: (1) amorphous composites such as polymer solutions, emulsions, and colloidal suspensions and (2) systems in which the self-assembly is based on the amphiphilic nature of surfactants and lipids.
This updated new edition of the well established and highly readable introductory text book on polymer science is ideal for those requiring a broad overview of the subject.
Following on from the success of the earlier editions, The Chemistry of Polymers, fourth edition, continues to explore Price: $. The book, packed with theory and practical aspects in a crisp and concise manner, aims to take the reader on an intense scientific expedition.
The compilation provides an insight into the chemistry and physics of materials and presents up-to-date status reports which would, undoubtedly, be useful to practitioners, teachers and students.Purchase Polymer Science: A Comprehensive Reference - 1st Edition.
Print Book & E-Book. ISBNPage 6. spectacular growth of modern computer and telecommunications industries and, consequently, to the information revolution. For many years after the invention of the transistor, the major intellectual challenge facing researchers in condensed-matter and materials physics was to understand the physical properties of nearly perfect single crystals of elements, simple .